<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:1fecbd6e-9605-43d1-bdd5-15814f1297c7,g:1373cff0-b903-452f-97fe-d681b3456c91-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://seer.bio/role/CoverPage" xlink:type="simple" xlink:href="seer-20220118.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://seer.bio/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_12aac3b6-f2f9-47a8-a6a0-387d3220d970" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_DocumentType_12aac3b6-f2f9-47a8-a6a0-387d3220d970" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_97edd08c-c3f1-4da1-b794-1c7be81abd6a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_DocumentPeriodEndDate_97edd08c-c3f1-4da1-b794-1c7be81abd6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_97a85ec1-6399-447e-a1be-e6f019a1e006" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityRegistrantName_97a85ec1-6399-447e-a1be-e6f019a1e006" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_4180e346-6d56-44aa-9894-1e7e17576db7" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityFileNumber_4180e346-6d56-44aa-9894-1e7e17576db7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_e8a7b50a-5ec1-4453-b981-8a16226360b5" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityIncorporationStateCountryCode_e8a7b50a-5ec1-4453-b981-8a16226360b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_9fb28f2a-75b5-4d22-90c6-2830e615b675" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityTaxIdentificationNumber_9fb28f2a-75b5-4d22-90c6-2830e615b675" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_826d71dc-e09a-4c8f-9cf9-77292bd37ef3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityAddressAddressLine1_826d71dc-e09a-4c8f-9cf9-77292bd37ef3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_39b59160-5efd-441c-b313-8f7a80dba97b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityAddressAddressLine2_39b59160-5efd-441c-b313-8f7a80dba97b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_a5e617f6-0c72-4d54-9d9d-0b57fed2eabd" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityAddressCityOrTown_a5e617f6-0c72-4d54-9d9d-0b57fed2eabd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_c4eb88b6-76fd-4e5a-9501-a2d9d3e47339" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityAddressStateOrProvince_c4eb88b6-76fd-4e5a-9501-a2d9d3e47339" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_8bb674dc-d571-4898-a7b8-6d88597e68a8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityAddressPostalZipCode_8bb674dc-d571-4898-a7b8-6d88597e68a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_1da8cdfd-35e4-48b3-9181-f4d6bfeaabe3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_CityAreaCode_1da8cdfd-35e4-48b3-9181-f4d6bfeaabe3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_8f547db4-8dd6-4890-936c-18eb16ca415e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_LocalPhoneNumber_8f547db4-8dd6-4890-936c-18eb16ca415e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_6714d5de-e598-4cdb-adbd-3335a77c1065" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_WrittenCommunications_6714d5de-e598-4cdb-adbd-3335a77c1065" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_72c2b4b2-b4d8-4988-9fd8-8e6d16730e6c" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_SolicitingMaterial_72c2b4b2-b4d8-4988-9fd8-8e6d16730e6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_852a22dd-7a1f-4b12-84e0-25dc0e526406" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_PreCommencementTenderOffer_852a22dd-7a1f-4b12-84e0-25dc0e526406" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_1a6eaaa7-f139-470f-81cc-18db80226f9b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_1a6eaaa7-f139-470f-81cc-18db80226f9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_82f2f29f-3111-4da3-a813-c46486b7af48" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_Security12bTitle_82f2f29f-3111-4da3-a813-c46486b7af48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_ae9dd885-684f-4a80-b8d0-25644528b8cb" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_TradingSymbol_ae9dd885-684f-4a80-b8d0-25644528b8cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_65567dde-e629-4006-9ba6-bae4716ae876" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityEmergingGrowthCompany_65567dde-e629-4006-9ba6-bae4716ae876" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_5a47f74a-d5cc-4ee4-8010-5aa717fc6f22" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityExTransitionPeriod_5a47f74a-d5cc-4ee4-8010-5aa717fc6f22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_81411da7-6785-4f5d-a0c6-55982e7b4ae1" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_EntityCentralIndexKey_81411da7-6785-4f5d-a0c6-55982e7b4ae1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_0b0a1af4-9f85-40f3-9091-3a46aefc0dc3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_DocumentFiscalYearFocus_0b0a1af4-9f85-40f3-9091-3a46aefc0dc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_17c658ef-8285-4e0d-b4ba-5379397c94c5" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_DocumentFiscalPeriodFocus_17c658ef-8285-4e0d-b4ba-5379397c94c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_b98001f8-da73-420a-b982-6e2b26446d27" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_AmendmentFlag_b98001f8-da73-420a-b982-6e2b26446d27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_769559aa-645e-4f66-b5e4-d9ad87d53d89" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4fcc8005-8517-4a4c-a3d0-b0269487c041" xlink:to="loc_dei_DocumentInformationTable_769559aa-645e-4f66-b5e4-d9ad87d53d89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_f41fcdc6-dbfa-4054-acf3-d3ad2e29e236" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_769559aa-645e-4f66-b5e4-d9ad87d53d89" xlink:to="loc_dei_DocumentInformationLineItems_f41fcdc6-dbfa-4054-acf3-d3ad2e29e236" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_c5682c78-2027-41ed-8f7c-61af03d6e2b8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_f41fcdc6-dbfa-4054-acf3-d3ad2e29e236" xlink:to="loc_dei_AmendmentFlag_c5682c78-2027-41ed-8f7c-61af03d6e2b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
