<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:d43f78e1-5eff-46e5-9cef-133f4592fb9b,g:e347290f-2073-4c43-b6b2-c855c42606d7-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://seer.bio/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="seer-20220630.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_11f34928-7335-4405-9b7d-2498f02575c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_21a8e11a-7f1c-4ef5-95a5-08513da8dada" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_11f34928-7335-4405-9b7d-2498f02575c7" xlink:to="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_21a8e11a-7f1c-4ef5-95a5-08513da8dada" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_e3930d8c-8b38-4168-8ce9-fee7a7569a45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_11f34928-7335-4405-9b7d-2498f02575c7" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_e3930d8c-8b38-4168-8ce9-fee7a7569a45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_46a5cd96-692e-4865-a140-083a975579e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_11f34928-7335-4405-9b7d-2498f02575c7" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_46a5cd96-692e-4865-a140-083a975579e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_25f2b295-fca4-43a6-a443-667b2059afd7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_11f34928-7335-4405-9b7d-2498f02575c7" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_25f2b295-fca4-43a6-a443-667b2059afd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_190b1b87-feed-4515-a0b6-cadbd170b54d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_11f34928-7335-4405-9b7d-2498f02575c7" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_190b1b87-feed-4515-a0b6-cadbd170b54d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_8a44e1b0-708e-434a-8525-290c596dc11b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_aa69d749-40c6-4b19-9380-dee463de07f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8a44e1b0-708e-434a-8525-290c596dc11b" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_aa69d749-40c6-4b19-9380-dee463de07f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_581080e5-9c73-4c2d-9725-8bcc1a2ec17d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8a44e1b0-708e-434a-8525-290c596dc11b" xlink:to="loc_us-gaap_AdditionalPaidInCapital_581080e5-9c73-4c2d-9725-8bcc1a2ec17d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_c692de84-61a8-4f00-b718-96667ddfd021" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8a44e1b0-708e-434a-8525-290c596dc11b" xlink:to="loc_us-gaap_CommonStockValue_c692de84-61a8-4f00-b718-96667ddfd021" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_58ea39ee-98c6-4cfb-be06-624e557bb48f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8a44e1b0-708e-434a-8525-290c596dc11b" xlink:to="loc_us-gaap_PreferredStockValue_58ea39ee-98c6-4cfb-be06-624e557bb48f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_6468ee6f-1ebe-407e-8751-5427fe7356aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8a44e1b0-708e-434a-8525-290c596dc11b" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_6468ee6f-1ebe-407e-8751-5427fe7356aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_0b894f5c-bc71-4375-bdee-272c9900a465" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_52864d62-0180-4354-babc-1a985901e5e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0b894f5c-bc71-4375-bdee-272c9900a465" xlink:to="loc_us-gaap_CommitmentsAndContingencies_52864d62-0180-4354-babc-1a985901e5e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_20c10655-b209-4fd7-b69e-1b172e6c3000" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0b894f5c-bc71-4375-bdee-272c9900a465" xlink:to="loc_us-gaap_StockholdersEquity_20c10655-b209-4fd7-b69e-1b172e6c3000" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_3d93f134-d06d-444b-bfc1-e12bf7e77c20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0b894f5c-bc71-4375-bdee-272c9900a465" xlink:to="loc_us-gaap_Liabilities_3d93f134-d06d-444b-bfc1-e12bf7e77c20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_ae37aaf0-78b7-4ad1-a503-84a7a5500caa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_ae37aaf0-78b7-4ad1-a503-84a7a5500caa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_33d17507-e7be-4ee5-bd60-adaf90e85a7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:to="loc_us-gaap_InventoryNet_33d17507-e7be-4ee5-bd60-adaf90e85a7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_07218f23-5794-4664-ac81-c86b6c126c62" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_07218f23-5794-4664-ac81-c86b6c126c62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_b33157bb-2a24-4334-8cdd-7e8f03e987b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_b33157bb-2a24-4334-8cdd-7e8f03e987b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueFromRelatedPartiesCurrent_ab8f6b11-a589-4d79-b806-c0d1f0e6393e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueFromRelatedPartiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:to="loc_us-gaap_DueFromRelatedPartiesCurrent_ab8f6b11-a589-4d79-b806-c0d1f0e6393e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_909bbd28-9c6d-4423-8bd1-3255592f0c2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_909bbd28-9c6d-4423-8bd1-3255592f0c2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_ed8b2f81-a069-4b0f-8912-b61c41b31a86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_362f1034-963c-4d88-b998-eec4c2115dae" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_ed8b2f81-a069-4b0f-8912-b61c41b31a86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_d2b1d842-fa8c-4680-a9ca-57541c409286" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_dfecdf90-7b71-47cc-9e1f-4c482130a13d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d2b1d842-fa8c-4680-a9ca-57541c409286" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_dfecdf90-7b71-47cc-9e1f-4c482130a13d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_bab40bbc-bca4-498f-812f-d6711be2c275" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d2b1d842-fa8c-4680-a9ca-57541c409286" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_bab40bbc-bca4-498f-812f-d6711be2c275" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_d0d98fdf-4484-401e-8432-910c43534f34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d2b1d842-fa8c-4680-a9ca-57541c409286" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_d0d98fdf-4484-401e-8432-910c43534f34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_b434796b-bb53-4e7e-8717-848fb47c1ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d2b1d842-fa8c-4680-a9ca-57541c409286" xlink:to="loc_us-gaap_LongTermInvestments_b434796b-bb53-4e7e-8717-848fb47c1ffc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_338b6f52-2ae9-4650-921d-e1e0071355b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d2b1d842-fa8c-4680-a9ca-57541c409286" xlink:to="loc_us-gaap_AssetsCurrent_338b6f52-2ae9-4650-921d-e1e0071355b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_139612ce-3486-453c-a939-708d24e4f353" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d2b1d842-fa8c-4680-a9ca-57541c409286" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_139612ce-3486-453c-a939-708d24e4f353" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_d8d481c7-4a89-4db9-87ce-3a277f530b80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3a3f0e4e-eb42-422c-9ed4-b8d4fb1ca673" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d8d481c7-4a89-4db9-87ce-3a277f530b80" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3a3f0e4e-eb42-422c-9ed4-b8d4fb1ca673" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_41f03853-970e-41e3-b391-eb4d57b6e29a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d8d481c7-4a89-4db9-87ce-3a277f530b80" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_41f03853-970e-41e3-b391-eb4d57b6e29a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_46498c44-ae71-41e4-88c3-7056b567d0cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d8d481c7-4a89-4db9-87ce-3a277f530b80" xlink:to="loc_us-gaap_LiabilitiesCurrent_46498c44-ae71-41e4-88c3-7056b567d0cf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="seer-20220630.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_cbf06557-40b0-4307-9600-87e5fe71bd94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_86211d74-59fe-4c96-924d-e2b12f261e87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_cbf06557-40b0-4307-9600-87e5fe71bd94" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_86211d74-59fe-4c96-924d-e2b12f261e87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_aaf0bded-b246-405c-85bc-4d9b28e3e6b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_cbf06557-40b0-4307-9600-87e5fe71bd94" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_aaf0bded-b246-405c-85bc-4d9b28e3e6b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_bfad6846-48f7-4a05-8930-f3079bc3498b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingExpense_15086ff6-a4ff-4efd-946a-1006b00b9243" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_bfad6846-48f7-4a05-8930-f3079bc3498b" xlink:to="loc_us-gaap_OtherNonoperatingExpense_15086ff6-a4ff-4efd-946a-1006b00b9243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_66ef8e85-e007-4a05-bf62-d29c2ea95e49" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_bfad6846-48f7-4a05-8930-f3079bc3498b" xlink:to="loc_us-gaap_InvestmentIncomeInterest_66ef8e85-e007-4a05-bf62-d29c2ea95e49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f69a71d5-ffd9-4928-b8df-482b9544c36e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_127dba6b-a914-42bd-a3b9-50475824017d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f69a71d5-ffd9-4928-b8df-482b9544c36e" xlink:to="loc_us-gaap_OperatingIncomeLoss_127dba6b-a914-42bd-a3b9-50475824017d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_a83e3bb1-b40b-4a4d-a061-437d8ecdd683" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f69a71d5-ffd9-4928-b8df-482b9544c36e" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_a83e3bb1-b40b-4a4d-a061-437d8ecdd683" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_a7a31a9c-472a-493a-89d4-28aecf8e30ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_c802bd91-e40b-427b-9d21-bc7a7527b7f9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a7a31a9c-472a-493a-89d4-28aecf8e30ee" xlink:to="loc_us-gaap_OperatingExpenses_c802bd91-e40b-427b-9d21-bc7a7527b7f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_ef84567f-4396-4221-8f3c-4b9e577a0c5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a7a31a9c-472a-493a-89d4-28aecf8e30ee" xlink:to="loc_us-gaap_GrossProfit_ef84567f-4396-4221-8f3c-4b9e577a0c5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_39ad4444-21b9-428f-b497-06b62a4b5b0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_88685cb6-bdf2-4c88-9018-5579c80330e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_39ad4444-21b9-428f-b497-06b62a4b5b0e" xlink:to="loc_us-gaap_CostOfRevenue_88685cb6-bdf2-4c88-9018-5579c80330e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ff1ee71c-aee8-4d8a-a55a-2e0215edb42a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_39ad4444-21b9-428f-b497-06b62a4b5b0e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ff1ee71c-aee8-4d8a-a55a-2e0215edb42a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_6d6321d7-ff28-476f-a335-fca78d60d97a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_24f46568-cdba-49cf-bba1-22ae8357e5c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_6d6321d7-ff28-476f-a335-fca78d60d97a" xlink:to="loc_us-gaap_NetIncomeLoss_24f46568-cdba-49cf-bba1-22ae8357e5c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_a3c384fb-4ded-471a-b7fc-a49565dbdf14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_6d6321d7-ff28-476f-a335-fca78d60d97a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_a3c384fb-4ded-471a-b7fc-a49565dbdf14" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="seer-20220630.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3feb8511-a0ef-4fe5-b84d-3f2adfa70359" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_b3536ced-db86-4236-94ab-40f5464a0176" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3feb8511-a0ef-4fe5-b84d-3f2adfa70359" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_b3536ced-db86-4236-94ab-40f5464a0176" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_444be524-24ab-4e67-b2e8-0992b2b23cce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3feb8511-a0ef-4fe5-b84d-3f2adfa70359" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_444be524-24ab-4e67-b2e8-0992b2b23cce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_cc493857-783f-4955-8959-1afc41d970f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3feb8511-a0ef-4fe5-b84d-3f2adfa70359" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_cc493857-783f-4955-8959-1afc41d970f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9ff5128-931a-417e-8546-a72e689532a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_fed56838-8c7a-4896-bf17-207c5f4176d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9ff5128-931a-417e-8546-a72e689532a1" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_fed56838-8c7a-4896-bf17-207c5f4176d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_ProceedsFromReturnOnProfit_f0bcbd05-209f-425d-a433-ee4eeb79847a" xlink:href="seer-20220630.xsd#seer_ProceedsFromReturnOnProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9ff5128-931a-417e-8546-a72e689532a1" xlink:to="loc_seer_ProceedsFromReturnOnProfit_f0bcbd05-209f-425d-a433-ee4eeb79847a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_6a11ebf6-c038-49bd-a7cc-20be0a457f72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9ff5128-931a-417e-8546-a72e689532a1" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_6a11ebf6-c038-49bd-a7cc-20be0a457f72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_d7681ff6-b01c-4723-a33d-cb2904400dad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9ff5128-931a-417e-8546-a72e689532a1" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_d7681ff6-b01c-4723-a33d-cb2904400dad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_fc69dab8-4d60-4043-bc64-5f7081c42f16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9ff5128-931a-417e-8546-a72e689532a1" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_fc69dab8-4d60-4043-bc64-5f7081c42f16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_0d42b618-9613-42bc-8300-2f364e4a0912" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_0d42b618-9613-42bc-8300-2f364e4a0912" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_4ad7557c-e4f9-46b2-b3ea-bf369adb166a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_4ad7557c-e4f9-46b2-b3ea-bf369adb166a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_2df4ad86-54db-448a-a4d0-5a191c4d1fc1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_2df4ad86-54db-448a-a4d0-5a191c4d1fc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_d4a52dde-e6d5-47d4-b4fb-9af0eafe6483" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_d4a52dde-e6d5-47d4-b4fb-9af0eafe6483" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_3d9e8d4b-a9ec-48a0-acaf-38583a5a4e96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_3d9e8d4b-a9ec-48a0-acaf-38583a5a4e96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_7180b729-5e5a-41a7-9578-f28d87313322" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_7180b729-5e5a-41a7-9578-f28d87313322" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_4099f6e0-2a2b-4d40-b43e-fe4c4d242c8c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_4099f6e0-2a2b-4d40-b43e-fe4c4d242c8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6dc3d435-c9b9-4e43-89dd-837d6fee3b2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_NetIncomeLoss_6dc3d435-c9b9-4e43-89dd-837d6fee3b2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_14e2b4ad-3f66-44c4-9212-b0312d6c183b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_14e2b4ad-3f66-44c4-9212-b0312d6c183b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_25ca027b-3a5c-4a88-90ff-c7be0a3d4876" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_25ca027b-3a5c-4a88-90ff-c7be0a3d4876" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDepreciationAndAmortization_15b70114-bd7f-450b-b18b-da24a7c579d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherDepreciationAndAmortization"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_OtherDepreciationAndAmortization_15b70114-bd7f-450b-b18b-da24a7c579d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties_eb43e234-97a3-4ec2-b590-5555ababbafb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties_eb43e234-97a3-4ec2-b590-5555ababbafb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_89c36b0b-96d7-463e-baa1-88ccaaf78ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_89c36b0b-96d7-463e-baa1-88ccaaf78ffa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_2ff156e0-8bc8-4002-a8d8-b11584227b50" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_OperatingLeaseExpense_2ff156e0-8bc8-4002-a8d8-b11584227b50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_8c7b8dd4-2adc-4cab-847b-7149bbd821f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherReceivables"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherReceivables_8c7b8dd4-2adc-4cab-847b-7149bbd821f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_c77b1c87-595a-43f2-b0ad-587fef0badd5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_ShareBasedCompensation_c77b1c87-595a-43f2-b0ad-587fef0badd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentLiabilities_66acbda4-450a-476e-8707-2d3576f7e255" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherCurrentLiabilities"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_071e5c6e-d74d-42b6-a7f5-dcc9bd761342" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentLiabilities_66acbda4-450a-476e-8707-2d3576f7e255" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3fe27cee-f11f-400c-9183-6f542d849714" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a91ad725-e742-434e-9053-478e729af220" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3fe27cee-f11f-400c-9183-6f542d849714" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a91ad725-e742-434e-9053-478e729af220" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_cc0b31f2-fe4f-4783-a52a-25f97b977ac4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3fe27cee-f11f-400c-9183-6f542d849714" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_cc0b31f2-fe4f-4783-a52a-25f97b977ac4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4e375417-0914-4461-a202-b6e53956aaee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3fe27cee-f11f-400c-9183-6f542d849714" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4e375417-0914-4461-a202-b6e53956aaee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c346b6aa-d1d4-4428-bce1-b4e748c42662" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_3a0ce2db-d316-4b71-b984-f4de06c9647c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c346b6aa-d1d4-4428-bce1-b4e748c42662" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_3a0ce2db-d316-4b71-b984-f4de06c9647c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_de19ec72-5b4a-4e3f-82fc-ba1f4515708c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c346b6aa-d1d4-4428-bce1-b4e748c42662" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_de19ec72-5b4a-4e3f-82fc-ba1f4515708c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsFinancialAssetsMeasuredatFairValueOnaRecurringBasisDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#FairValueMeasurementsandFairValueofFinancialInstrumentsFinancialAssetsMeasuredatFairValueOnaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsFinancialAssetsMeasuredatFairValueOnaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_64d3cc9c-a3df-4ebb-99d6-ebb43f49791f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_5914c6ec-bfd6-49d3-8d7d-9a4477242c16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_64d3cc9c-a3df-4ebb-99d6-ebb43f49791f" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_5914c6ec-bfd6-49d3-8d7d-9a4477242c16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_3d442352-a2cf-49f1-a2b5-08f5dd17ff0a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_64d3cc9c-a3df-4ebb-99d6-ebb43f49791f" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_3d442352-a2cf-49f1-a2b5-08f5dd17ff0a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_145795ca-19f0-43ac-8dab-b55e57244929" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_64e4a43c-56e5-40c9-975f-a0c3aade22e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_145795ca-19f0-43ac-8dab-b55e57244929" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_64e4a43c-56e5-40c9-975f-a0c3aade22e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_734d10df-e82c-4c55-ba80-72eb2f6f5731" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_145795ca-19f0-43ac-8dab-b55e57244929" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_734d10df-e82c-4c55-ba80-72eb2f6f5731" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_c4a0d9ba-d26d-43f3-8679-fd2d4ac2c505" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_145795ca-19f0-43ac-8dab-b55e57244929" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_c4a0d9ba-d26d-43f3-8679-fd2d4ac2c505" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofInventoryDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#OtherFinancialStatementInformationScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_2bed4a71-133d-4cbb-be51-0c7a0364a2c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_49881794-84dd-4916-a62f-c9b2628555d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_2bed4a71-133d-4cbb-be51-0c7a0364a2c3" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_49881794-84dd-4916-a62f-c9b2628555d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_69d4a7ce-d145-4bad-a8eb-9e9d7d1abffa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_2bed4a71-133d-4cbb-be51-0c7a0364a2c3" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_69d4a7ce-d145-4bad-a8eb-9e9d7d1abffa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_28cd9aef-a315-4a0b-ab81-bfb4cab120d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_2bed4a71-133d-4cbb-be51-0c7a0364a2c3" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_28cd9aef-a315-4a0b-ab81-bfb4cab120d3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ede7aa06-129f-44a1-b419-82c292a25a66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_6e413b97-6d0c-4f7c-8ab2-15f5e4f0862d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_ede7aa06-129f-44a1-b419-82c292a25a66" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_6e413b97-6d0c-4f7c-8ab2-15f5e4f0862d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_fa3ba145-1e05-4dc6-8694-648b546181f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_ede7aa06-129f-44a1-b419-82c292a25a66" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_fa3ba145-1e05-4dc6-8694-648b546181f0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofAccruedCompensationDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#OtherFinancialStatementInformationScheduleofAccruedCompensationDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofAccruedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_c852dd38-dd49-41d3-b913-17f81ec62c34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_c580667f-5692-4b54-8c7f-d216938e1fc9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_c852dd38-dd49-41d3-b913-17f81ec62c34" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_c580667f-5692-4b54-8c7f-d216938e1fc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_3e53f657-3b9e-43a8-a954-b7af39f43cc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_c852dd38-dd49-41d3-b913-17f81ec62c34" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_3e53f657-3b9e-43a8-a954-b7af39f43cc6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedCompensation_13d10794-7a70-442e-977b-ee04ab164650" xlink:href="seer-20220630.xsd#seer_AccruedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_c852dd38-dd49-41d3-b913-17f81ec62c34" xlink:to="loc_seer_AccruedCompensation_13d10794-7a70-442e-977b-ee04ab164650" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedPropertyAndEquipment_9a2236c4-4611-4ff4-aad6-a829c9c800fb" xlink:href="seer-20220630.xsd#seer_AccruedPropertyAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_c852dd38-dd49-41d3-b913-17f81ec62c34" xlink:to="loc_seer_AccruedPropertyAndEquipment_9a2236c4-4611-4ff4-aad6-a829c9c800fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_29cb3217-6d32-44fc-9dc8-87df124769a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_c852dd38-dd49-41d3-b913-17f81ec62c34" xlink:to="loc_us-gaap_TaxesPayableCurrent_29cb3217-6d32-44fc-9dc8-87df124769a5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CommitmentsandContingenciesComponentsofLeaseCostDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#CommitmentsandContingenciesComponentsofLeaseCostDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CommitmentsandContingenciesComponentsofLeaseCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_b4d20ae7-4f35-4bb9-ba25-4a0c5ac6391f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_648ccc02-e69e-454b-9f36-419025cd2dd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_b4d20ae7-4f35-4bb9-ba25-4a0c5ac6391f" xlink:to="loc_us-gaap_VariableLeaseCost_648ccc02-e69e-454b-9f36-419025cd2dd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_a87a46ed-0873-4708-bd36-287a10d2549d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_b4d20ae7-4f35-4bb9-ba25-4a0c5ac6391f" xlink:to="loc_us-gaap_ShortTermLeaseCost_a87a46ed-0873-4708-bd36-287a10d2549d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_ad17697e-d169-4a7f-9564-8428c539c4a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_b4d20ae7-4f35-4bb9-ba25-4a0c5ac6391f" xlink:to="loc_us-gaap_OperatingLeaseCost_ad17697e-d169-4a7f-9564-8428c539c4a1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CommitmentsandContingenciesFutureMinimumCommitmentsUnderFacilityOperatingLeaseDetails" xlink:type="simple" xlink:href="seer-20220630.xsd#CommitmentsandContingenciesFutureMinimumCommitmentsUnderFacilityOperatingLeaseDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CommitmentsandContingenciesFutureMinimumCommitmentsUnderFacilityOperatingLeaseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2391c580-5c99-46b8-b9ee-5b7ec0d23bc8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_252d2876-3798-4747-8238-63026f817b30" xlink:href="seer-20220630.xsd#seer_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2391c580-5c99-46b8-b9ee-5b7ec0d23bc8" xlink:to="loc_seer_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_252d2876-3798-4747-8238-63026f817b30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_8652ff92-7624-4cd0-bc57-cc1cf976d0c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2391c580-5c99-46b8-b9ee-5b7ec0d23bc8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_8652ff92-7624-4cd0-bc57-cc1cf976d0c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_5ff9cc0b-cbe7-484e-b07d-bb08eda822b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2391c580-5c99-46b8-b9ee-5b7ec0d23bc8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_5ff9cc0b-cbe7-484e-b07d-bb08eda822b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_4291e810-cefc-47e4-8477-40db88ff8c87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2391c580-5c99-46b8-b9ee-5b7ec0d23bc8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_4291e810-cefc-47e4-8477-40db88ff8c87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_93a94a70-b0ba-452d-ae69-ce6f48e20df1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2391c580-5c99-46b8-b9ee-5b7ec0d23bc8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_93a94a70-b0ba-452d-ae69-ce6f48e20df1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_3012d094-d7df-4b6e-a9c1-00b0ac4d44e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2391c580-5c99-46b8-b9ee-5b7ec0d23bc8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_3012d094-d7df-4b6e-a9c1-00b0ac4d44e4" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
