<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:e76abb6f-cead-4699-9351-17bf53b77680,g:1037c8cf-3063-4d31-901d-66c0f41f1eda-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://seer.bio/role/CoverPage" xlink:type="simple" xlink:href="seer-20231107.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://seer.bio/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_6f34de1a-38c8-4e34-a449-4b11f7eec59a" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_DocumentType_6f34de1a-38c8-4e34-a449-4b11f7eec59a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_654f4942-0633-4067-83d0-cd0fa12bf0ad" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_DocumentPeriodEndDate_654f4942-0633-4067-83d0-cd0fa12bf0ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_9916c474-5555-41f3-b446-8bedde76e6ab" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityRegistrantName_9916c474-5555-41f3-b446-8bedde76e6ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_ec5fe993-a671-43c2-958b-74141485b945" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityFileNumber_ec5fe993-a671-43c2-958b-74141485b945" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_73d69738-f482-41fa-8c4c-204c44f52bec" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityIncorporationStateCountryCode_73d69738-f482-41fa-8c4c-204c44f52bec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_94531d55-2bc5-44bc-890c-6d1c2feab131" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityTaxIdentificationNumber_94531d55-2bc5-44bc-890c-6d1c2feab131" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_313ac90c-ebb7-4f66-a246-1f2cf5285d88" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityAddressAddressLine1_313ac90c-ebb7-4f66-a246-1f2cf5285d88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_fb375ede-ae09-4f23-92de-34437c11eabc" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityAddressAddressLine2_fb375ede-ae09-4f23-92de-34437c11eabc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_46248be7-c6bd-44c0-a7b6-ce58305b9980" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityAddressCityOrTown_46248be7-c6bd-44c0-a7b6-ce58305b9980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_69cc1113-8a2d-4eac-958d-ba1c1ec43abe" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityAddressStateOrProvince_69cc1113-8a2d-4eac-958d-ba1c1ec43abe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_95cb74e6-b06e-4923-b3bf-e372732bb544" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityAddressPostalZipCode_95cb74e6-b06e-4923-b3bf-e372732bb544" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_61724cf1-72ba-47cb-bf6e-a817a0194c17" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_CityAreaCode_61724cf1-72ba-47cb-bf6e-a817a0194c17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_58b30b71-fe87-4d4a-b98c-4b3ac4abf056" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_LocalPhoneNumber_58b30b71-fe87-4d4a-b98c-4b3ac4abf056" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_49e34643-f2e6-46ee-a157-7ecdd4b5564e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_WrittenCommunications_49e34643-f2e6-46ee-a157-7ecdd4b5564e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_9ff2d688-1dc1-4105-a835-2ca3cb54e0f5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_SolicitingMaterial_9ff2d688-1dc1-4105-a835-2ca3cb54e0f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_e4c99c6f-7241-4148-89c3-ea69d867fcdd" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_PreCommencementTenderOffer_e4c99c6f-7241-4148-89c3-ea69d867fcdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_b5b9acf6-623b-441d-a750-ca8722b5069d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_b5b9acf6-623b-441d-a750-ca8722b5069d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_9cdf79e3-6d29-493c-8395-186e2eb12202" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_Security12bTitle_9cdf79e3-6d29-493c-8395-186e2eb12202" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_85d73303-5ab5-43ac-9b3d-2a7b59fc4d17" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_TradingSymbol_85d73303-5ab5-43ac-9b3d-2a7b59fc4d17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_d8ecd8b2-93d6-450d-aee9-c7555b07eec9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityEmergingGrowthCompany_d8ecd8b2-93d6-450d-aee9-c7555b07eec9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_5a1606a0-6d3f-46df-8798-5e346885675f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_EntityCentralIndexKey_5a1606a0-6d3f-46df-8798-5e346885675f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_4ea4d66e-5e78-4732-82ad-8cb7d6e747b0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_DocumentFiscalYearFocus_4ea4d66e-5e78-4732-82ad-8cb7d6e747b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_e3eda296-86c7-4991-b8cf-da12946422ee" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_DocumentFiscalPeriodFocus_e3eda296-86c7-4991-b8cf-da12946422ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_97f3d17d-e3e8-48c5-9b42-ed5beb8a030b" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a71b035a-1200-482d-8ca0-43c70ab1c8c5" xlink:to="loc_dei_AmendmentFlag_97f3d17d-e3e8-48c5-9b42-ed5beb8a030b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
